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A man with worsening weakness.

G Proietti1, M Puliti, F Tulli

  • 1Divisione di Medicina-Emodialisi, Ospedale Bernardini, Azienda Sanitaria Locale RMG, Palestrina, Roma.

Minerva Medica
|April 26, 2000
PubMed
Summary

POEMS syndrome, a rare disorder, can present with hypoparathyroidism, leading to rhabdomyolysis. This case highlights a 74-year-old man diagnosed with POEMS syndrome and hypoparathyroidism.

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Area of Science:

  • Endocrinology
  • Neurology
  • Oncology

Background:

  • POEMS syndrome is a rare multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes.
  • Interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF) are implicated in POEMS syndrome pathogenesis.
  • Endocrinopathies are common, with diabetes being the most frequent; hypoparathyroidism is exceptionally rare.

Observation:

  • A 74-year-old male presented with leg weakness, found to have rhabdomyolysis secondary to hypoparathyroidism.
  • The patient also exhibited organomegaly, distal leg neuropathy, and a monoclonal light chain band on protein electrophoresis.
  • These clinical and laboratory findings were consistent with POEMS syndrome.

Findings:

  • This case report details a rare presentation of POEMS syndrome associated with hypoparathyroidism and subsequent rhabdomyolysis.
  • The diagnosis was confirmed by the presence of key POEMS criteria: organomegaly, neuropathy, and monoclonal gammopathy.
  • This underscores the diverse endocrine manifestations of POEMS syndrome.

Implications:

  • Recognizing hypoparathyroidism as a potential endocrinopathy in POEMS syndrome is crucial for accurate diagnosis and management.
  • Early identification of POEMS syndrome can prevent severe complications like rhabdomyolysis.
  • Further research into the link between POEMS syndrome and parathyroid dysfunction is warranted.

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