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[Drug hypersensitivity syndrome to valproic acid]
N Picart1, B Périole, J Mazereeuw
1Service de Dermatologie, CHU Rangueil, Toulouse.
Presse Medicale (Paris, France : 1983)
|April 26, 2000
Abstract
Background:
Drug-induced hypersensitivity syndrome is an uncommon but potentially life-threatening idiosyncratic drug reaction. It is usually due to aromatic anti-convulsants. We report the second case induced by sodium valproate, a non-aromatic anticonvulsant.
Case Report:
A 28-year-old woman was treated with sodium valproate for 5 weeks. She suddenly developed a generalized maculo-papulous eruption with fever, node enlargement, hypereosinophilia and altered liver function.
Discussion:
Drug-induced hypersensitivity is rarely induced by valproic acid. The time-course and positive patch tests using the diluted drug establish the diagnosis.