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Nucleic acid synthesis for investigations of gene functions
1Health Sciences University of Hokkaido, Japan.
Nucleic Acids Symposium Series
|April 26, 2000
Abstract:
The chemical syntheses of genes encoding human c-Ha-ras and T4 endonuclease V are described. These genes have been used for studies of mutagenesis by damaged bases and recognition of nucleic acids by proteins. The modes of interaction of photo-damaged DNA and cognate antibodies have also been investigated by biochemical and physicochemical approaches.