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Synthesis of oligodeoxyribonucleotides bearing a functional group at 2'-position by post-synthetic modification
H Ozaki1, S Momiyama, K Yokotsuka
1Faculty of Engineering, Gunma University, Kiryu, Japan.
Nucleic Acids Symposium Series
|April 26, 2000
Abstract:
A novel 2'-thio-2'-deoxyuridine derivative bearing a reactive ester at 2'-position was synthesized and incorporated into oligodeoxyribonucleotides (ODNs) for the post-synthetic modification of ODNs. This ODNs was reacted with several amines to give ODNs having a functional group at 2'-position.