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The interaction of benzimidazole compounds with DNA: intercalation and groove binding modes
1Department of Chemistry, Faculty of Science, Yamaguchi University, Japan.
Nucleic Acids Symposium Series
|April 26, 2000
Abstract:
Benzimidazole compounds (Fig. 1) have been synthesized to study their DNA-binding properties. Results obtained with spectroscopy and viscosity measurements indicate that the binding mode varies from intercalation to groove-binding, depending on the number of benzimidazole rings (conformation and size of compounds).