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Toward artificial ribonucleases: design and synthesis of 2'-O-methyloligonucleotides with a terpyridine-copper(II)
T Tamura1, T Furukawa, Y Komatsu
1Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Nucleic Acids Symposium Series
|April 26, 2000
Abstract:
In order to construct an antisense 2'-O-methyloligonucleotide with an internal terpyridine-Cu(II) complex, a novel synthon was synthesized. This synthon was a 2'-deoxy-uridine-3'-phosphoramidite derivative with a terpyridine group at the 5'-O and a dimethoxytritylated hydroxypropyl group at the C-5. The antisense agent cleaved the RNA site-specifically and in a moderate yield.