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Synthesis and properties of oligonucleotides containing 2'-pyrenylalkyluridine
K Yamana1, K Asazuma, H Nakano
1Department of Applied Chemistry, Himeji Institute of Technology, Hyogo, Japan.
Nucleic Acids Symposium Series
|April 26, 2000
Abstract:
The synthesis, binding and fluorescence properties of oligonucleotides containing the uridine modified at the 2'-position by a pyrene group using different length of linker arm have been described. It is demonstrated that the oligonucleotides possessing a C3-amide group at the 2'-position display an enhanced signal of the pyrene monomer fluorescence upon binding to DNA segments.