Related Experiment Video

Updated: Jul 28, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

Study on RNA structure by pyrene-labeled 2'-O-methyloligoribonucleotides

R Iwase1, A Mahara, K Yamana

  • 1Department of Polymer Science and Engineering, Kyoto Institute of Technology, Japan.

Nucleic Acids Symposium Series
|April 26, 2000
PubMed
Summary

Pyrene-labeled 2'-O-methyloligoribonucleotides (OMUpy) act as fluorescent probes to detect single-stranded RNA regions. Hybridization with complementary sequences significantly increases OMUpy fluorescence, enabling RNA structure analysis.

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