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Metal ion-directed DNA recognition by chelating DNA ligands
1Department of Applied Chemistry and Biochemistry, Faculty of Engineering, Kumamoto University, Japan.
Nucleic Acids Symposium Series
|April 26, 2000
Abstract:
Novel DNA ligand bearing oxine and pyridinium group has been synthesized. The DNA binding of this ligand was regulated by coexisting Cu2+ over the range of more than three orders in magnitude of binding constant. This should be due to the metal-mediated dimerization of the ligand and concomitant emergence of cationic charges. There were definite two DNA binding modes for the ligand dimer depending on the P/L ratio.