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Synthesis and DNA-binding of acridine-netropsin hybrid molecules
Y Kubota1, S Kawamura, R Uchida
1Department of Chemistry, Faculty of Science, Yamaguchi University, Japan.
Nucleic Acids Symposium Series
|April 26, 2000
Abstract:
We have designed and synthesized acridine-netropsin hybrid molecules. Spectroscopic (absorption, CD, flow dichroism and fluorescence) measurements reveal that hybrid molecules interact with DNA by both intercalation and minor-groove binding and shows enhanced preference for AT-rich sites.