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Updated: Aug 13, 2026
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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
Published on: October 25, 2013
Vancomycin-dependent enterococcal strains: case report and review
C J Yowler1, R J Blinkhorn, R B Fratianne
1Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109-1998, USA.
The Journal of Trauma
|April 26, 2000
Summary
The first isolation of vancomycin-resistant Enterococcus (VRE) displaying vancomycin resistance (VDE) was reported in a burn unit. This emergence highlights the need for intensive care units to monitor for VDE.
Area of Science:
- Infectious Diseases
- Microbiology
- Clinical Medicine
Background:
- Vancomycin-resistant Enterococci (VRE) are a growing concern in healthcare settings.
- Previous studies indicate risk factors for VRE colonization and infection.
Observation:
- This study reports the first isolation of vancomycin-resistant Enterococcus (VRE) with vancomycin-intermediate resistance (VDE) from a burn unit.
- The isolation occurred following continuous vancomycin administration and prior VRE detection.
Findings:
- The emergence of VDE in a burn unit signifies a potential new challenge in managing resistant infections.
- Clinical and microbiological surveillance is crucial for identifying emerging resistant pathogens.
Implications:
- Intensive care units (ICUs) must enhance vigilance for VDE, a potentially serious nosocomial pathogen.
- Understanding the epidemiology and risk factors for VDE is critical for infection control strategies.
- This finding necessitates a re-evaluation of treatment protocols in ICUs managing VRE.
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