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An efficient method for the synthesis of sulbactam pivoxil
L S Changov1, B K Vassileva, M N Confino
1University of Chemical Technology and Metallurgy, Sofia, Bulgaria. lschangov@hotmail.com
Farmaco (Societa Chimica Italiana : 1989)
|April 27, 2000
Abstract:
Sulbactam pivoxil, a prodrug of the beta-lactamase inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting the reaction mixture with water and isolating the product by filtration. Dimethyl sulfoxide was found to be the solvent of choice among several aprotic organic solvents.