Related Experiment Video
Updated: Jul 23, 2026
04:30
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Local Angiopeptin Delivery Using Coated Stents Reduces Neointimal Proliferation in Overstretched Porcine Coronary
De Scheerder I1, Wilczek, Van Dorpe J
1UH Gasthuisberg, Department of Cardiology, 49, Herestraat, 3000, Leuven, Belgium.
The Journal of Invasive Cardiology
|June 1, 1996
Summary
Angiopeptin-loaded stents effectively inhibit myointimal thickening after vascular injury. Local angiopeptin concentrations reduce neointimal proliferation, promoting larger lumen diameters in stented arteries.
Area of Science:
- Cardiovascular Research
- Biomedical Engineering
- Pharmacology
Background:
- Systemic angiopeptin administration inhibits myointimal thickening post-arterial injury in animal models.
- Investigating local angiopeptin delivery for vascular healing is crucial.
Purpose of the Study:
- To evaluate the efficacy of angiopeptin-loaded stents in inhibiting myointimal hyperplasia.
- To determine local angiopeptin concentrations and their impact on vascular healing after stent implantation.
Main Methods:
- Tantalum balloon-expandable stents were coated with angiopeptin (250 µg) and polymer.
- Stents were implanted in porcine coronary arteries, with tissue concentrations measured over 8 days.
- 20 pigs received either angiopeptin-loaded or blank stents, followed by 6-week assessment.
Main Results:
- Local angiopeptin concentrations were high initially (10.7 pg/ml) and declined over 8 days (2.0 pg/ml).
- Angiopeptin-treated pigs showed significantly larger minimal luminal diameter (2.20 mm vs 1.57 mm) after 6 weeks.
- Post-mortem morphometry confirmed increased lumen area (1.00 mm² vs 0.43 mm²) in the angiopeptin group.
Conclusions:
- Polymer-coated stents can effectively deliver angiopeptin locally.
- High, sustained local angiopeptin concentrations inhibit stent-induced myointimal proliferation.
- Angiopeptin-loaded stents represent a promising strategy for improving vascular healing post-intervention.
