The use of colchicine in treatment of experimental toxoplasmosis

Colchicine was given in 2 doses (3 and 15 micrograms/mouse) at the time of infection or 48 hours late. It proved effective in both doses, but better results were obtained with early treatment. The mortality rates were 30% & 30%, and Toxoplasma carriers among the surviving mice was 28.6% and 42.9% with high and low doses respectively. When the treatment was given 48 hours after infection, the mortality rates were 50% and 60%, Toxoplasma carriers were 40% and 50% with high and low doses respectively.