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Corneal thickness measured by interferometry.

D G Green, B R Frueh, J M Shapiro

Journal of the Optical Society of America

|February 1, 1975

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A novel optical method uses laser interference fringes to accurately measure human corneal thickness in vivo. This technique also successfully measures optically opaque corneas, advancing ophthalmic diagnostics.

Area of Science:

Ophthalmology
Biomedical Optics
Medical Imaging

Background:

Accurate measurement of corneal thickness is crucial for diagnosing and managing various eye conditions.
Existing methods for measuring corneal thickness may have limitations, particularly with opaque corneas.

Purpose of the Study:

To develop and validate a new optical method for measuring the thickness of transparent biological structures, specifically the human cornea.
To assess the feasibility of this method for in vivo measurements and its capability in handling optically opaque corneas.

Main Methods:

Developed an optical technique utilizing coherent laser light and interference fringe analysis.
Placed the anterior corneal surface at the focus of the laser beam.
Measured the spacing of interference fringes generated by reflected light to calculate corneal thickness.

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Main Results:

Successfully measured corneal thickness in both frog and human corneas.
Demonstrated correlation between optical measurements and established histologic and pachometer methods.
Confirmed the technique's capability to measure optically opaque corneas.

Conclusions:

The developed optical method provides a reliable and non-invasive approach for measuring corneal thickness.
This technique offers a significant advancement, particularly for assessing opaque corneas, expanding diagnostic possibilities.