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Updated: Aug 11, 2026
09:50
Procedure for Human Saphenous Veins Ex Vivo Perfusion and External Reinforcement
Published on: October 1, 2014
[Primary varicose veins--changes in the venous wall and elastic behavior]
1Klinik und Poliklinik für Allgemein- und Abdominalchirurgie, Johannes Gutenberg-Universität Mainz. Kirsch@ach.klinik.uni-mainz.de
Summary
Varicose veins develop due to changes in the vein wall
Area of Science:
- Vascular Biology
- Histopathology
- Biomaterials Science
Context:
- Varicosis (varicose veins) is a common condition with unclear etiology.
- Understanding the structural changes in vein walls is crucial for explaining varicose vein development.
Purpose:
- To investigate the elastic properties and histomorphological alterations of the extracellular matrix in the long saphenous vein wall.
- To compare normal veins with varicose veins, including segments above and below competent valves.
Summary:
- Varicose veins exhibit increased rigidity compared to normal veins.
- Histomorphological analysis revealed increased total fibers and reduced, fragmented elastic fibers in varicose veins.
- No significant difference in rigidity was observed between varicose veins above a competent valve and normal veins below it.
Impact:
- Findings suggest that changes in the vein wall's extracellular matrix are primary factors in varicose vein development.
- The role of venous valves appears secondary to intrinsic vein wall alterations in the pathogenesis of varicosis.
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