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The thiazolidinediones: a new class of antidiabetic agents
1Department of Medicine, Birmingham Heartlands Hospital.
Hospital Medicine (London, England : 1998)
|May 2, 2000
Abstract:
Insulin resistance is a fundamental feature of type 2 diabetes and is strongly associated with metabolic disorders which predict increased cardiovascular risk, including hypertension and dyslipidaemia. A new class of insulin-sensitizing agents, the thiazolidinediones, reduce insulin resistance and improve glycaemia both as monotherapy and in combination with sulphonylureas or metformin.