Mutations in the human TWIST gene

Area of Science:

• Genetics
• Molecular Biology

Background:

• Accurate reporting of genetic mutations is crucial for scientific reproducibility.
• Previous publication contained an error in amino acid translation.

Purpose of the Study:

• To correct a previously reported nucleotide and amino acid change.
• To ensure the accuracy of genetic mutation data.

Main Methods:

• Review of nucleotide sequence data.
• Analysis of codon translation for amino acid sequence.

Main Results:

• The nucleotide change 490C>T was incorrectly reported.
• The correct amino acid change resulting from 490C>T is Q164X, not Q165X.

Conclusions:

• The corrected amino acid change (Q164X) is now accurately documented.
• This correction ensures the integrity of genetic information in the scientific record.