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Assay Development for High Content Quantification of Sod1 Mutant Protein Aggregate Formation in Living Cells
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[Familial amyotrophic lateral sclerosis associated with mutant Cu/Zn superoxide dismutase as a conformational

T Koide1, S Igarashi, K Kikugawa

  • 1Department of Neurology, Niigata University, Japan.

Rinsho Shinkeigaku = Clinical Neurology
|May 3, 2000
PubMed

Insights

Mutant copper-zinc superoxide dismutase (SOD) forms toxic cytoplasmic aggregates in cells, potentially driving familial amyotrophic lateral sclerosis (FALS) pathogenesis. This research sheds light on the molecular mechanisms underlying FALS disease progression.

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Cell Biology

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