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A model for particulate structure in chromatin.

K E Van Holde, C G Sahasrabuddhe, B R Shaw

    Nucleic Acids Research
    |November 1, 1974
    PubMed
    Summary
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    A novel model suggests DNA winds around a protein core in nuclease-resistant chromatin particles. This core is formed by the hydrophobic regions of histone molecules, explaining chromatin structure.

    Area of Science:

    • Biochemistry
    • Molecular Biology
    • Structural Biology

    Background:

    • Chromatin particles are fundamental units of DNA packaging in eukaryotes.
    • Understanding the precise structure of chromatin is crucial for comprehending gene regulation and DNA accessibility.

    Purpose of the Study:

    • To propose a novel structural model for nuclease-resistant chromatin particles.
    • To elucidate the role of histone hydrophobic regions in DNA organization within chromatin.

    Main Methods:

    • Theoretical modeling based on existing biochemical and biophysical data.
    • Analysis of histone protein structures and their potential interactions.

    Main Results:

    • A model where DNA is helically wound around a central protein core.

    Related Experiment Videos

  • Identification of the hydrophobic regions of histone molecules as the primary component of this protein core.

    • Conclusions:

    • The proposed model offers a new perspective on chromatin particle structure.
    • The hydrophobic interactions of histones are key to forming the core around which DNA is organized.