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Cellular recognition and activation within the lymphoid system
American Journal of Clinical Pathology
|May 1, 1975
Abstract:
The present study is concerned with cellular recognition and activation within the lymphoid system. Data presented indicate that in human peripheral blood phagocytes recognize and preferentially bind phagocytes, and thymus-derived (T) lymphocytes recognize and preferentially bind other T lymphocytes rather than thymus-indepedent (B) lymphocytes. Recognition of non-self results in activation of lymphoid cells; recent data using a calcium ionophore, A23 187, suggest that calcium may act as an intracellular messenger by which signals for cellular activation are transmitted from the cell surface to the nucleus.