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The role of the thymus in spontaneous autoimmune thyroiditis
Annals of the New York Academy of Sciences
|February 28, 1975
Abstract:
In two models of genetically determined, spontaneous autoimmune thyroiditis, neonatal thymectomy increases the incidience and severity of disease. The simpliest explanation is that the thymus, or thymus-derived cells, normally exert a suppressive effect on the autoimmune response to thyroglobulin in addition to the helper function that is necessary to initiate the autoimmune reaction.