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Related Experiment Videos

Neonatal sepsis: an etiological study.

S K Anwer1, S Mustafa, S Pariyani

  • 1Department of Paediatric, Abbasi Shaheed Hospital, Karachi.

JPMA. the Journal of the Pakistan Medical Association
|May 5, 2000
PubMed
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Neonatal sepsis is increasingly caused by Gram-positive organisms. Periodic review of neonatal sepsis data is crucial for updating antibiotic policies to combat evolving pathogens.

Area of Science:

  • Neonatalogy
  • Infectious Diseases
  • Microbiology

Background:

  • Neonatal sepsis remains a significant cause of morbidity and mortality in newborns.
  • Understanding the changing spectrum of causative organisms is vital for effective treatment.

Purpose of the Study:

  • To conduct a periodic review of neonatal sepsis cases.
  • To assess shifts in the predominant infecting organisms responsible for neonatal sepsis.

Main Methods:

  • A prospective study was conducted at HMC and ASH, Karachi.
  • Blood cultures were obtained from neonates suspected of sepsis.
  • Causative organisms were isolated and identified.

Main Results:

  • Out of 109 sepsis episodes, 68 were early-onset and 41 were late-onset.

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  • Early-onset sepsis had nearly equal Gram-negative and Gram-positive isolates; Klebsiella sp. was common.
  • Late-onset sepsis was predominantly caused by Gram-positive organisms, including Staphylococcus aureus and S. epidermidis.

    • Conclusions:

    • Gram-positive organisms are now the primary cause of neonatal sepsis.
    • Klebsiella sp. remains a common cause of early-onset sepsis.
    • Regular review of antimicrobial susceptibility data is essential for refining antibiotic treatment guidelines.