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Related Experiment Videos

Magnesium sulphate versus diazepam for eclampsia.

L Duley1, D Henderson-Smart

  • 1Resource Centre for Randomised Trials, Institute of Health Sciences, Old Road, Headington, Oxford, UK, OX3 7LF. lelia.duley@ndm.ox.ac.uk

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary

Magnesium sulfate significantly reduces recurrent seizures in women with eclampsia compared to diazepam. This treatment also shows a trend towards reduced maternal mortality and improved infant outcomes.

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Area of Science:

  • Obstetrics and Gynecology
  • Neurology
  • Pharmacology

Background:

  • Eclampsia is a serious condition characterized by seizures in pregnant or postpartum women.
  • Anticonvulsant medications are crucial for managing eclamptic seizures and preventing recurrence.

Purpose of the Study:

  • To compare the efficacy and safety of magnesium sulfate versus diazepam in the management of eclampsia.
  • To evaluate the impact of magnesium sulfate on seizure recurrence, maternal mortality, and neonatal outcomes.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) identified from Cochrane databases.
  • Inclusion criteria: RCTs comparing intravenous or intramuscular magnesium sulfate with diazepam for women diagnosed with eclampsia.
  • Quality assessment and data extraction performed by two independent reviewers.

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Main Results:

  • Five RCTs involving 1236 women were analyzed, with most trials demonstrating good quality.
  • Magnesium sulfate significantly reduced the recurrence of convulsions compared to diazepam (RR 0.45, 95% CI 0.35-0.58).
  • A borderline statistically significant reduction in maternal mortality was observed with magnesium sulfate (RR 0.60, 95% CI 0.36-1.00), along with fewer low Apgar scores and shorter neonatal unit stays.

Conclusions:

  • Magnesium sulfate is substantially more effective than diazepam in treating eclampsia.
  • The findings support the use of magnesium sulfate as a primary anticonvulsant therapy for eclamptic patients.