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Oxytocin for promoting successful lactation.
M J Renfrew1, S Lang, M Woolridge
1Mother and Infant Research Unit, University of Leeds, 22 Hyde Terrace, Leeds, West Yorkshire, UK, LS2 9LN. m.j.renfrew@leeds.ac.uk
The Cochrane Database of Systematic Reviews
|May 5, 2000
Summary
Oral or nasal oxytocin may help increase milk production in breastfeeding women. However, unrestricted breastfeeding support is likely more beneficial for augmenting lactation.
Area of Science:
- Reproductive Medicine
- Endocrinology
- Lactation Physiology
Background:
- Oxytocin plays a crucial role in milk ejection by causing contractions around alveoli and milk ducts.
- Lactation failure can occur due to insufficient oxytocin levels.
Purpose of the Study:
- To evaluate the efficacy of oral or nasal oxytocin administration in augmenting lactation.
Main Methods:
- A systematic review of randomized and quasi-randomized trials was conducted.
- Trials involving variable doses and administration methods of oxytocin versus placebo in breastfeeding women were included.
- Quality assessment and data extraction were performed by two independent reviewers.
Main Results:
- Four trials with 639 participants were analyzed, with potential for bias noted.
- Sublingual and buccal oxytocin preparations showed an increase in milk production.
- Higher doses (100 IU) appeared slightly more effective than lower doses (10 IU) and did not increase breast pain.
Conclusions:
- Sublingual or buccal oxytocin may be beneficial for augmenting lactation when needed.
- Emphasis on unrestricted breastfeeding and support can potentially reduce the need for oxytocin supplementation.