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Interventions for treating schistosomiasis mansoni.

H Saconato1, A Atallah

  • 1Clinical Medicine, Universidade Federal do Rio Grande do Norte, Rua Ewerton Cortez, 1483 - Tirol, Natal, Rio Grande do Norte, Brazil, 59. 020-620. saconato@summer.com.br

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
This summary is machine-generated.

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Praziquantel and oxamniquine are effective treatments for Schistosomiasis mansoni infection. While both drugs are safe, lower doses of oxamniquine may be less effective than praziquantel.

Area of Science:

  • Tropical Medicine
  • Infectious Diseases
  • Parasitology

Background:

  • Schistosomiasis is a potentially fatal parasitic disease transmitted by freshwater snails.
  • The intestinal form of schistosomiasis affects the intestine, liver, and spleen.

Purpose of the Study:

  • To evaluate the efficacy of oxamniquine and praziquantel in treating Schistosomiasis mansoni.
  • To compare the effectiveness of these two drugs against placebo and each other.

Main Methods:

  • Systematic review of randomized and quasi-randomized controlled trials.
  • Searched multiple databases including Cochrane, Medline, and Lilacs.
  • Independent data extraction and quality assessment by two reviewers.

Main Results:

Related Experiment Videos

  • Praziquantel and oxamniquine demonstrated significant efficacy in curing Schistosomiasis mansoni compared to placebo.
  • Praziquantel (40 mg/Kg) showed higher efficacy than oxamniquine (15 mg/Kg) in individuals over 14 in Africa.
  • No significant difference in efficacy was observed between praziquantel and oxamniquine (30 mg/Kg) in Brazil.

Conclusions:

  • Both praziquantel and oxamniquine are effective and safe treatments for Schistosomiasis mansoni.
  • Lower doses of oxamniquine (under 30 mg/Kg) may be less effective.
  • Further research may be needed to establish optimal dosing regimens.