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Vaccines for preventing cholera.

P Graves1, J Deeks, V Demicheli

  • 1Dept of Preventive Medicine & Biometrics, University of Colorado Health Sciences Center, Box C 245, 4200 E Ninth Ave, Denver, CO 80262, USA. Patricia.Graves@uchsc.edu

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
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Cholera vaccines, particularly oral killed whole cell types, offer significant protection against cholera. While parenteral vaccines have more side effects, oral vaccines are safe and effective for up to three years, especially with boosters.

Area of Science:

  • Infectious Diseases
  • Vaccinology
  • Public Health

Background:

  • Parenteral cholera vaccines offer moderate, short-term immunity.
  • Oral cholera vaccines (killed whole cell or live recombinant) are emerging alternatives.
  • Understanding vaccine efficacy and safety is crucial for disease prevention.

Purpose of the Study:

  • To evaluate the effectiveness of cholera vaccines in preventing cholera cases.
  • To assess the impact of cholera vaccines on preventing cholera-related deaths.
  • To review the safety profiles of different cholera vaccine types.

Main Methods:

  • Systematic review of randomized and quasi-randomized controlled trials.
  • Searched multiple databases (Cochrane, Medline, Embase) and contacted experts.

Related Experiment Videos

  • Included studies on parenteral and oral cholera vaccines (killed or live) in adults and children.

    • Main Results:

    • 32 trials involving over 2.6 million participants were analyzed.
    • Cholera vaccines demonstrated 51% efficacy in preventing cholera within 12 months.
    • Oral killed whole cell vaccines provided longer protection (up to 3 years) than parenteral types, with fewer adverse effects.

    Conclusions:

    • Killed whole cell cholera vaccines are effective and safe.
    • Live oral recombinant vaccines are safe, but efficacy data is limited.
    • Vaccine protection can last up to 2-4 years, with boosters enhancing duration.