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Vaccines for preventing anthrax.

T Jefferson¹, V Demicheli, J Deeks

¹Army Medical Directorate 5, Ministry of Defence, Building 21a, Keogh Barracks, Ash Vale, HANTS, UK, GU12 5RR. zorria@epinet.co.uk

The Cochrane Database of Systematic Reviews

|May 5, 2000

Summary

This summary is machine-generated.

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See all related articles

Anthrax vaccines effectively reduce the risk of contracting the bacterial disease. While killed anthrax vaccines show effectiveness, they may increase adverse effects compared to placebo.

Area of Science:

Infectious Disease Epidemiology
Vaccinology
Public Health

Background:

Anthrax is a potentially fatal bacterial skin disease.
Current anthrax vaccines lack clear comparative effectiveness and safety data.

Purpose of the Study:

To assess the effects of human anthrax vaccines in healthy adults and children.
Evaluate comparative effectiveness and safety of available anthrax vaccines.

Main Methods:

Systematic review of randomized and quasi-randomized trials.
Searched multiple databases (Cochrane, Medline, Embase) and handsearched journals.
Independent data extraction and quality assessment by multiple authors.

Main Results:

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Vaccination significantly reduced the risk of anthrax compared to placebo (RR 0.16).

Killed anthrax vaccines showed higher incidence/severity of adverse effects (OR 5.15).

Over 5% of vaccine recipients reported adverse effects; inoculation route did not impact effectiveness.

Conclusions:

Killed anthrax vaccines are effective in preventing anthrax with manageable adverse effects.
Future research should focus on developing and testing novel anthrax vaccines.