Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vaccines for preventing plague.

T Jefferson1, V Demicheli, M Pratt

  • 1Army Medical Directorate 5, Ministry of Defence, Building 21a, Keogh Barracks, Ash Vale, HANTS, UK, GU12 5RR. zorria@epinet.co.uk

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Viral cultures, cycle threshold values and viral load estimation for assessing SARS-CoV-2 infectiousness in haematopoietic stem cell and solid organ transplant patients: a systematic review.

The Journal of hospital infection·2022
Same author

Viral cultures for assessing fomite transmission of SARS-CoV-2: a systematic review and meta-analysis.

The Journal of hospital infection·2022
Same author

Worldwide surveillance of self-reported sitting time: a scoping review.

The international journal of behavioral nutrition and physical activity·2020
Same author

Evaluation of Swab and Tissue Excision Methods for Recovering Microorganisms from Washed and Sanitized Beef Carcasses <sup>1,</sup> <sup>2</sup>.

Journal of food protection·2019
Same author

A research agenda to guide progress on childhood obesity prevention in Latin America.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2017
Same author

Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth.

Oncogene·2017
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles

No clinical trials exist to confirm plague vaccine effectiveness. Observational data suggest killed plague vaccines may be safer and more effective than live attenuated vaccines, but long-term effects remain unknown.

Area of Science:

  • Infectious Disease Epidemiology
  • Vaccinology
  • Public Health

Background:

  • Plague remains endemic in multiple global regions, posing a significant public health threat.
  • Existing plague vaccines include live attenuated, killed, and F1 fraction types, administered through various methods.

Purpose of the Study:

  • To systematically review and assess the efficacy and tolerability of vaccines developed to prevent plague.

Main Methods:

  • Comprehensive literature search of major databases (Medline, Embase, Cochrane) and expert consultation.
  • Inclusion criteria focused on randomized controlled trials comparing plague vaccines against placebo or other interventions.
  • Trial eligibility and data extraction were performed by three independent reviewers.

Related Experiment Videos

Main Results:

  • The systematic review identified no eligible randomized controlled trials for inclusion.
  • Consequently, no direct evidence exists to evaluate the effectiveness or comparative tolerability of any plague vaccine.

Conclusions:

  • Insufficient evidence prevents definitive conclusions on plague vaccine efficacy and safety.
  • Observational data hint that killed plague vaccines might offer better efficacy and fewer adverse effects than live attenuated vaccines.
  • Long-term effects of all plague vaccine types require further investigation.