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Vitamin E for intermittent claudication.

J Kleijnen¹, D Mackerras

¹NHS Centre for Reviews and Dissemination, University of York, Heslington, York, North Yorkshire, UK, YO10 5DD. jk13@york.ac.uk

The Cochrane Database of Systematic Reviews

|May 5, 2000

Summary

Vitamin E may offer some benefit for intermittent claudication pain, but current evidence is insufficient to confirm its effectiveness. More high-quality research is needed to determine if vitamin E is a reliable treatment for this condition.

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Area of Science:

Vascular Medicine
Nutritional Supplementation

Background:

Intermittent claudication is characterized by leg pain during exercise due to ischemia.
Vitamin E is hypothesized to improve exercise tolerance and alleviate pain through various mechanisms.

Purpose of the Study:

To evaluate the efficacy of vitamin E in managing intermittent claudication.

Main Methods:

Systematic review of controlled trials comparing vitamin E with placebo.
Searched multiple databases and reference lists for relevant studies.
Independent data extraction and quality assessment by reviewers.

Main Results:

Five studies with 265 participants (predominantly male, average age 57) were included.
Trials were small, of generally poor quality, with varied doses and outcome measures.

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All trials indicated positive effects on at least one outcome; no serious adverse effects were reported.

Conclusions:

Vitamin E is inexpensive and appears safe, with potential benefits for intermittent claudication.
However, insufficient evidence exists to definitively establish vitamin E as an effective treatment.
Further rigorous research is required to confirm its therapeutic role.