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Related Experiment Videos

Mycobacterium vaccae immunotherapy for treating tuberculosis.

G de Bruyn1, P Garner

  • 1Department of Medicine, Baylor College of Medicine, Fondren-Brown Building, 6565 Fannin St, Houston, TX 77030, USA. guyd@bcm.tmc.edu

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary

Immunotherapy using Mycobacterium vaccae showed no benefit for tuberculosis patients. This review found no effect on mortality or sputum conversion, with a high rate of adverse reactions observed in clinical trials.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Clinical Trials

Background:

  • Mycobacterium vaccae has been proposed for immunotherapy against tuberculosis.
  • The bacterium is also considered for other mycobacterial infections.

Purpose of the Study:

  • To evaluate the efficacy of Mycobacterium vaccae immunotherapy in treating tuberculosis.
  • To synthesize evidence from randomized and quasi-randomized controlled trials.

Main Methods:

  • Searched major databases (Cochrane, Medline, Embase) and contacted experts.
  • Included randomized and quasi-randomized trials of killed Mycobacterium vaccae in tuberculosis patients.
  • Assessed trial quality and extracted data.

Main Results:

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  • Four trials met inclusion criteria.
  • No significant effect on mortality was observed (RR 1.01, 95% CI 0.50 to 2.04).
  • Inconsistent effects on sputum negativity and culture conversion were noted, alongside a high incidence of adverse reactions.

Conclusions:

  • Mycobacterium vaccae immunotherapy does not appear to offer clinical benefits for tuberculosis patients.
  • The observed adverse reactions warrant careful consideration.