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Related Experiment Videos

Olanzapine for schizophrenia.

L Duggan1, M Fenton, R M Dardennes

  • 1Developmental Disabilities Division, St Andrew's Hospital, Billing Rd, Northampton, Northamptonshire, UK, NN1 5DG. lornaduggan@yahoo.co.uk

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
This summary is machine-generated.

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Olanzapine may be effective for schizophrenia with fewer side effects than older drugs, but causes more weight gain. High dropout rates limit firm conclusions on clinical effects, necessitating long-term trials.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Trials

Background:

  • Olanzapine is an atypical antipsychotic known for efficacy without the extrapyramidal side effects of typical antipsychotics.
  • Schizophrenia and schizophreniform psychoses are serious mental health conditions requiring effective treatment.

Purpose of the Study:

  • To compare the clinical effects and safety of olanzapine against placebo and other antipsychotic drugs.
  • To evaluate olanzapine's efficacy in treating schizophrenia and schizophreniform psychoses.

Main Methods:

  • Systematic review of randomized clinical trials comparing olanzapine to placebo or other antipsychotics.
  • Electronic searches of major biomedical databases (1980-1999) and contact with pharmaceutical companies.
  • Data extraction and analysis using relative risk, confidence intervals, and weighted mean differences.

Related Experiment Videos

Main Results:

  • Olanzapine showed superiority to placebo in 'no important clinical response' but had higher rates of dizziness and dry mouth.
  • Efficacy similar to typical antipsychotics for 'no important clinical response', with fewer extrapyramidal side effects than haloperidol.
  • Olanzapine associated with significant weight gain over 3-12 months compared to comparators, though not always statistically significant.

Conclusions:

  • Olanzapine offers antipsychotic benefits with potentially fewer extrapyramidal side effects than typical drugs, but with increased weight gain.
  • High participant attrition in trials complicates definitive conclusions regarding clinical effects.
  • There is a need for large, long-term randomized trials to establish firm conclusions on olanzapine's efficacy and safety.