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Domicilary oxygen for chronic obstructive pulmonary disease
A J Crockett1, J R Moss, J M Cranston
1Respiratory Unit, Flinders Medical Centre, Bedford Park, Adelaide, South Australia, Australia, 5042. alan.crockett@flinders.edu.au
The Cochrane Database of Systematic Reviews
|May 5, 2000
Summary
Long-term oxygen therapy improves survival for severe hypoxemic COPD patients. It does not benefit those with moderate hypoxemia or nocturnal desaturation.
Area of Science:
- Pulmonary Medicine
- Critical Care Medicine
Background:
- Long-term domiciliary oxygen therapy is a primary treatment for hypoxemic COPD.
- COPD management often involves oxygen to address hypoxemia.
Purpose of the Study:
- To evaluate the impact of domiciliary oxygen therapy on survival and quality of life in COPD patients.
- Assessing the efficacy of home oxygen in COPD management.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) identified via the Cochrane Airways Group COPD register.
- Inclusion criteria: RCTs comparing long-term domiciliary oxygen therapy with control in hypoxemic COPD patients.
- Data extraction performed independently by two reviewers.
Main Results:
- Four RCTs were identified; data could not be aggregated due to heterogeneity.
- NOTT 1980 showed improved survival with continuous oxygen therapy vs. nocturnal.
- MRC 1981 demonstrated improved 5-year survival with domiciliary oxygen therapy vs. none.
Conclusions:
- Long-term oxygen therapy enhances survival in select COPD patients with severe hypoxemia (PaO2 < 8.0 kPa).
- Oxygen therapy did not improve survival in patients with moderate hypoxemia or nocturnal desaturation.