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Colloid solutions for fluid resuscitation.

F Bunn1, P Alderson, V Hawkins

  • 1Department of Epidemiology and Public Health, Institute of Child Health, 30 Guilford Street, London, UK, WC1N 1EH. f.bunn@ich.ucl.ac.uk

The Cochrane Database of Systematic Reviews
|May 5, 2000
PubMed
Summary
This summary is machine-generated.

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This review found no evidence that different colloid solutions vary in safety or effectiveness for fluid replacement. Larger trials are needed to detect potential differences in mortality between colloid types.

Area of Science:

  • Critical care medicine
  • Anesthesiology
  • Pharmacology

Background:

  • Colloids are frequently used for fluid volume replacement, but their benefits and risks remain debated.
  • Variations in molecular weight and circulatory persistence influence colloid safety and efficacy.

Purpose of the Study:

  • To compare the effects of different colloid solutions in patients requiring volume replacement.

Main Methods:

  • Systematic review of randomized and quasi-randomized trials comparing colloid solutions.
  • Searched Cochrane, MEDLINE, and EMBASE databases; contacted drug manufacturers.
  • Included critically ill and surgical patients; outcomes were mortality, blood transfusion, and adverse reactions.

Main Results:

Related Experiment Videos

  • 46 trials (2884 participants) were included; many trials were small and of poor quality.
  • No significant differences in mortality were found between albumin/PPF, hydroxyethyl starch (HES), or gelatin.
  • Limited data on blood transfusions and no reported adverse reactions.

Conclusions:

  • Current evidence does not demonstrate superiority of one colloid solution over another for safety or efficacy.
  • Wide confidence intervals do not exclude clinically significant differences.
  • Larger trials are necessary to definitively assess mortality differences.