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Protein restriction for diabetic renal disease
1Wessex Institute of Health Research and Development, University of Southampton, Mailpoint 728 Boldrewood, Southampton, UK, SO16 7PX. N.R.Waugh@soton.ac.uk
The Cochrane Database of Systematic Reviews
|May 5, 2000
Summary
Protein restriction (0.3-0.8g/kg) appears to slow diabetic nephropathy progression. Further research is needed on optimal protein levels, patient compliance, and long-term outcomes for non-insulin-dependent diabetes.
Area of Science:
- Nephrology
- Endocrinology
- Dietary Science
Background:
- Diabetic nephropathy is a leading cause of end-stage renal failure.
- Protein intake is a modifiable factor in kidney disease progression.
Purpose of the Study:
- To evaluate the efficacy of protein restriction in slowing diabetic nephropathy progression.
- To identify optimal protein intake levels and assess long-term outcomes.
Main Methods:
- Systematic review of MEDLINE and EMBASE databases (1974-1996).
- Inclusion of trials with insulin-dependent diabetes patients on low-protein diets (≥4 months).
- Analysis of renal function indicators like creatinine clearance.
Main Results:
- Protein-restricted diets (0.3-0.8g/kg/day) demonstrated a slowing effect on diabetic nephropathy progression.
- Short-term indicators like creatinine clearance were used to assess impact.
Conclusions:
- Reducing protein intake shows promise in delaying renal failure in diabetic nephropathy.
- Further studies are required to determine optimal protein levels, patient compliance, and long-term effects, particularly in non-insulin-dependent diabetes.