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Related Experiment Videos

Switching outpatients between atypical antipsychotics.

A M Bogan1, E Shellhorn, E S Brown

  • 1University of Texas Health Science Center, Houston, USA.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|May 9, 2000
PubMed
Summary

Switching patients with schizophrenia from sertindole to quetiapine was well tolerated in a small study. No patients worsened, and one showed improvement, suggesting this switch may be safe.

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Pharmacology

Background:

  • Limited data exist on switching atypical antipsychotics, excluding clozapine, despite its common clinical use.
  • Previous reports indicated potential symptom exacerbation when switching from clozapine to other atypical antipsychotics.

Observation:

  • Six patients with schizophrenia or schizoaffective disorder, bipolar type, were switched to quetiapine after a sertindole clinical trial.
  • The observation period ranged from two to ten weeks.

Findings:

  • No subjects experienced worsening of symptoms during the switch to quetiapine.
  • One patient demonstrated improvement in symptoms.
  • Reported side effects associated with the switch were mild.

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Implications:

  • Preliminary data suggest that switching between certain atypical antipsychotic agents may be a well-tolerated strategy.
  • Larger, controlled clinical trials are necessary to validate these findings and confirm tolerability.
  • This research informs clinical practice regarding antipsychotic medication management in schizophrenia and related disorders.