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Updated: Jul 11, 2026

Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II
Published on: February 26, 2018
Sister chromatid cohesion: the beginning of a long and beautiful relationship
1Department of Embryology, Howard Hughes Medical Institute, Carnegie Institution of Washington, Baltimore, MD 21210, USA. koshland@ciweb.edu
Abstract:
Our understanding of the mechanism of sister chromatid cohesion has advanced significantly with the recent identification and characterization of important regulatory factors, structural factors and chromosomal cohesion sites. These analyses reveal a surprisingly complex mechanism of cohesion that is just beginning to be elucidated and exciting connections between cohesion, cell-cycle regulation and other forms of DNA metabolism.
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