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Human zinc deficiency.

M Hambidge1

  • 1Section of Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

The Journal of Nutrition
|May 10, 2000
PubMed
Summary

Zinc is vital for human nutrition, impacting growth, immunity, and development. Understanding zinc deficiency is crucial for public health, requiring further research into metabolism and effective interventions.

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Area of Science:

  • Human Nutrition
  • Biochemistry
  • Public Health

Background:

  • Zinc plays a critical role in human health and nutrition.
  • Human zinc deficiency is a significant global health concern with complex implications.
  • Recent advancements have improved our understanding of zinc's importance.

Purpose of the Study:

  • To provide a comprehensive overview of zinc's significance in human nutrition.
  • To address key aspects of zinc deficiency, from biochemistry to public health.
  • To highlight areas for future research in zinc metabolism and homeostasis.

Main Methods:

  • Review of current literature on zinc biochemistry and biology.
  • Analysis of historical understanding and recent progress in zinc deficiency research.
  • Examination of clinical manifestations and diagnostic challenges of zinc deficiency.

Main Results:

  • Severe zinc deficiency presents a distinct clinical spectrum.
  • Mild zinc deficiency lacks ideal biomarkers, necessitating intervention studies.
  • Zinc deficiency impacts growth, immunity, cognitive function, and fetal development.
  • Public health significance is particularly high in developing nations.

Conclusions:

  • Further research is urgently needed to understand zinc metabolism, homeostasis, and bioavailability.
  • Improved strategies for preventing and managing zinc deficiency are essential.
  • Addressing zinc nutriture is critical for global public health and individual well-being.

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