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Simplification of the clinical phase of IVF and ICSI treatment in programmed cycles
V Vlaisavljević1, B Kovacic, V Gavrić-Lovrec
1Department of Reproductive Medicine and Gynecologic Endocrinology, Maribor Teaching Hospital, Maribor, Slovenia. vlai@sb-mb.sl
Objective:
To evaluate the success of a protocol for controlled ovarian hyperstimulation allowing patient self-selection into groups for ovulation stimulation planned 8 weeks and more in advance following cycle synchronization, drug self-administration as well as a reduced number of folliculometries.
Methods:
A total of 714 patients received the same stimulation protocol. In 260 cases GnRH-a was applied daily and in 454 as depot. In all patients FSH-HP was self-administered subcutaneously for ovarian stimulation. In 316 patients IVF and in 398 patients ICSI was performed.
Results:
The delivery rate per started cycle was higher in patients receiving depot GnRH-a in the IVF and ICSI group (30.2 vs. 23.4) than in those receiving subcutaneous GnRH-a (20.2 vs. 22.1).
Conclusion:
Programming of the IVF/ICSI cycle greatly simplifies treatment. A comparison of pregnancy rate and delivery rate per cycle between depot and subcutaneous daily application of GnRh-a did not confirm any statistically significant difference.