Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Matrix mini-tablets based on starch/microcrystalline wax mixtures.

C De Brabander1, C Vervaet, L Fiermans

  • 1Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Gent, Harelbekestraat 72, 9000, Gent, Belgium.

International Journal of Pharmaceutics
|May 10, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring twin-screw feeding behaviour across different loss-in-weight feeders.

International journal of pharmaceutics·2026
Same author

Semi-crystalline materials for pharmaceutical fused filament fabrication: Dissolution and porosity.

International journal of pharmaceutics·2024
Same author

Batch vs. continuous direct compression - a comparison of material processability and final tablet quality.

International journal of pharmaceutics: X·2024
Same author

Visualization of the granule temperature using thermal imaging to improve understanding of the granulation mechanism in continuous twin-screw melt granulation.

International journal of pharmaceutics·2023
Same author

Drying behaviour and visualization of surfactants after co-spray drying of surfactant-stabilized aqueous suspensions.

International journal of pharmaceutics·2023
Same author

Exploiting common ion addition to accelerate zolpidem hemitartrate release from Eudragit EPO extrudates.

International journal of pharmaceutics·2023

This study developed ibuprofen mini-tablets using waxes and starches for controlled drug release. Optimal formulations with specific waxes and concentrations achieved the slowest drug release, demonstrating potential for sustained delivery systems.

Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Mini-tablets offer advantages over pellets for drug delivery, particularly concerning scalability.
  • Controlling drug release rates is crucial for effective therapeutic outcomes.
  • Ibuprofen serves as a model drug for evaluating novel drug delivery formulations.

Purpose of the Study:

  • To prepare and characterize matrix mini-tablets for ibuprofen using microcrystalline waxes and starch derivatives.
  • To investigate the influence of formulation variables on in vitro drug release profiles.
  • To determine optimal conditions for achieving sustained drug release from mini-tablet formulations.

Main Methods:

  • Preparation of mini-tablets via melt granulation using a hot stage screw extruder, followed by milling and tabletting.

Related Experiment Videos

  • Utilized microcrystalline waxes with varying melting ranges and concentrations.
  • Incorporated different starches and starch mixtures, alongside varying ibuprofen concentrations (up to 70%).

    • Main Results:

    • Mini-tablet production was favored over pelletization due to scalability concerns.
    • Formulations containing microcrystalline wax with a melting range of 68-72°C exhibited the slowest in vitro ibuprofen release.
    • Increased wax concentration generally led to slower drug release, while higher ibuprofen concentrations (70%) resulted in faster release rates.

    Conclusions:

    • Matrix mini-tablets incorporating microcrystalline waxes and starch derivatives are a viable approach for controlled ibuprofen delivery.
    • Formulation parameters, including wax type, concentration, and drug loading, significantly impact drug release kinetics.
    • The developed mini-tablets demonstrate potential for creating sustained-release drug delivery systems.