Related Experiment Video
Updated: Aug 19, 2026

05:39
Murine Model of Wound Healing
Published on: May 28, 2013
[Effect of melatonin on wound healing and various biochemical characteristics of granulation-fibrous tissue in rats]
K R Hva1, E G Ol'shevskiĭ, L G Markina
1Research Centre for Biomedical Technology, Moscow.
Abstract:
The influence of melatonin application on wounds healing and biochemical composition of rat regenerating granulation tissue was studied. Melatonin decreased healing rate of wounds. The differences in electrophoretic pattern of proteins extracted by neutral saline solutions were detected. Melatonin increased quantity of neutral soluble collagen fraction and gene expression of minor types of collagen in normal skin. Spectrum of glycosaminoglycans' was changed, and earlier increase of chondroitinsulfats induced by administration of melatonin was observed.

