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Related Experiment Videos

[Opioid receptor knockout mice].

I Sora1

  • 1Department of Psychopharmacology, Tokyo Institute of Psychiatry, Japan.

Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology
|May 10, 2000
PubMed
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Mice lacking the mu-opioid receptor show no analgesic or reward effects from morphine, demonstrating its crucial role in mediating opiate actions. This research highlights the mu receptor

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Context:

  • Opioid receptors (mu, delta, kappa) are key targets for opiate drugs, influencing analgesia, reward, and physiological functions.
  • Gene-targeting technology enables the creation of opioid receptor knockout mice, serving as vital models for in vivo studies.
  • Understanding opioid receptor function is crucial for developing novel therapeutic strategies and managing opiate-related effects.

Purpose:

  • To elucidate the in vivo functions of mu, delta, and kappa opioid receptors using knockout mouse models.
  • To investigate the specific roles of the mu-opioid receptor in mediating the therapeutic and adverse effects of morphine.
  • To explore the involvement of the mu-opioid receptor in reward pathways and its interaction with other neurotransmitter systems.

Summary:

Related Experiment Videos

  • Mice lacking the mu-opioid receptor exhibit a paradoxical decrease in thermal nociception but an increased threshold for visceral stimuli.
  • Absence of the mu receptor in mice abolishes morphine-induced analgesia, reward, respiratory depression, constipation, immunosuppression, and physical dependence.
  • Mu-opioid receptor expression is essential for the analgesic effects mediated by delta and kappa receptors, and for cocaine and ethanol reward.

Impact:

  • The mu-opioid receptor is identified as the primary molecular target for most of morphine's effects, both beneficial and detrimental.
  • These findings underscore the critical role of the mu-opioid receptor in mediating analgesia, reward, and physiological responses to opiates.
  • Mu-opioid receptor knockout mice provide an indispensable tool for dissecting complex interactions within the endogenous opioid and dopamine systems, paving the way for new drug development.