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Extranasal T/NK-cell lymphoma presenting as intestinal diverticulum
1Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul. lys9908@cmc.cuk.ac.kr
Journal of Korean Medical Science
|May 10, 2000
Summary
A rare case of intestinal angiocentric T/NK-cell lymphoma perforated a sigmoid colon diverticulum. This lymphoma subtype is a distinct cause of bowel perforation.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Intestinal lymphomas are uncommon, and angiocentric T/NK-cell lymphoma is a rare subtype.
- Diverticular perforation is a common surgical emergency, but lymphoma is an unusual cause.
Observation:
- A 58-year-old man presented with panperitonitis due to sigmoid colon diverticulum perforation.
- Histology revealed diffuse infiltration of lymphoma cells with angiocentric growth and necrosis in the intestinal wall.
- Immunophenotyping showed CD56+, CD45RO+, CD3+, CD4-, CD8-, CD20-, CD30- cells with a germline TCR-gamma gene configuration.
Findings:
- The patient was diagnosed with intestinal angiocentric T/NK-cell lymphoma.
- Splenomegaly was detected during further staging.
- The findings suggest this lymphoma can present as a cause of diverticular perforation.
Implications:
- This case highlights intestinal angiocentric T/NK-cell lymphoma as a rare but important differential diagnosis for perforated diverticulitis.
- Recognition of this entity is crucial for appropriate patient management and treatment.
- Further research into the pathogenesis and clinical behavior of intestinal angiocentric T/NK-cell lymphoma is warranted.