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Cephotaxime-associated allergic interstitial nephritis and MPO-ANCA positive vasculitis
S Feriozzi1, A O Muda, V Gomes
1Nefrologia e Dialisi, Ospedale Belcolle, Viterbo, Italy. ancarani@isa.it
Abstract:
We report a case of reversible acute renal failure after cefotaxime treatment in a patient affected by non-Hodgkin lymphoma. Renal biopsy showed necrotizing vasculitis associated with eosinophil-rich interstitial inflammatory infiltrates and patchy infiltrates of CD20+ lymphoid cells. High serum p-ANCA titers were also detected. Drug withdrawal was closely related with recovery of renal function and disappearance of ANCA. Acute renal failure therefore represented a consequence of ANCA-mediated renal vasculitis and acute interstitial nephritis related to cefotaxime treatment.
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