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Total synthesis of spicamycin amino nucleoside
1Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Organic Letters
|May 11, 2000
Abstract:
[formula: see text] The first total synthesis of spicamycin amino nucleoside 2 has been achieved. The aminoheptose unit 5 was prepared stereoselectively from myo-inositol, and the characteristic N-glycoside linkage was constructed by way of Pd-catalyzed coupling reaction of 5 with 6-chloropurine derivative 6.