Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ageing and autoimmunity.

B Fixa, O Komárková, Z Nozicka

    Gerontologia
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Autoantibody prevalence increases with age, particularly in women over 61. Thyroid autoantibodies showed a notable rise in older individuals, aligning with global findings.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Multiple Non-ossifying Fibroma (Case-report).].

    Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2010
    Same author

    Comparison of the efficacy and safety of Eudragit-L-coated mesalazine tablets with ethylcellulose-coated mesalazine tablets in patients with mild to moderately active ulcerative colitis.

    Alimentary pharmacology & therapeutics·2006
    Same author

    A double-blind dose-escalating trial comparing novel mesalazine pellets with mesalazine tablets in active ulcerative colitis.

    Alimentary pharmacology & therapeutics·2005
    Same author

    [Nodular faciitis--rare localization on the eye (a case report)].

    Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti·2004
    Same author

    Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine.

    Gut·2004
    Same author

    [Giant myelolipoma of the adrenal gland].

    Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2003
    Same journal

    An electron microscopic investigation of age-dependent changes in the flight muscle of Musca domestica L.

    Gerontologia·1975
    Same journal

    A further note on the Orgel error hypothesis and senescence.

    Gerontologia·1975
    Same journal

    Effect of aging on brain respiration and carbohydrate metabolism of Syrian hamsters.

    Gerontologia·1975
    Same journal

    Testosterone uptake by prostatic tissue from young and old rats.

    Gerontologia·1975
    Same journal

    Ageing and cell-mediated immunity.

    Gerontologia·1975
    Same journal

    The effect of age on mitochondrial ultrastructure.

    Gerontologia·1975
    See all related articles

    Area of Science:

    • Immunology
    • Gerontology
    • Endocrinology

    Background:

    • Autoantibodies are immune system proteins that mistakenly target the body's own tissues.
    • Age is a known factor influencing immune system function and autoimmunity.
    • Previous studies suggest geographical variations in autoantibody prevalence.

    Purpose of the Study:

    • To investigate the prevalence of eight specific autoantibodies in a healthy Czechoslovakian population.
    • To determine if autoantibody occurrence varies across different age groups and sexes.
    • To compare findings with international autoantibody research.

    Main Methods:

    • Serological examination of 483 healthy individuals across three age strata (under 40, 41-60, over 61).
    • Testing for antibodies against thyroid epithelial cells, thyroid colloid, parietal cells, parotid interstitial duct cells, adrenal cells, nuclear antigens, mitochondria, and intrinsic factor.

    Related Experiment Videos

  • Statistical analysis to identify significant differences in prevalence based on age and sex.

    • Main Results:

    • A significantly higher prevalence of autoantibodies was observed in the oldest age group (over 61 years).
    • Autoantibody occurrence was more pronounced in women within the oldest age cohort.
    • A conspicuous increase was specifically noted for thyroid autoantibodies.

    Conclusions:

    • Aging is associated with an increased prevalence of autoantibodies in healthy individuals.
    • Women may be more susceptible to age-related autoantibody development.
    • The observed trends in autoantibody prevalence, especially for thyroid-related antibodies, are consistent across different geographic regions.