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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
11:56

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

Published on: October 25, 2013

[Drug-resistant bacteria of current topics and their resistance mechanisms--VRE]

Y Ike1

  • 1Department of Mycrobiolog, Gumma University Faculty of Medicine.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|May 11, 2000
PubMed

Insights

Vancomycin-resistant Enterococci (VRE) are rare in Japan, primarily found in imported chickens. Two main types, VanA and VanB, exhibit distinct resistance patterns to vancomycin and teicoplanin antibiotics.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Context:

  • Vancomycin-resistant Enterococci (VRE) have been infrequently detected in Japanese hospitals since 1996.
  • VRE are frequently isolated from imported chickens, particularly those from regions using avoparcin in animal feed.
  • Understanding VRE epidemiology in Japan is crucial due to potential public health implications.

Purpose:

  • To describe the prevalence and characteristics of VRE in Japan.
  • To differentiate between VanA and VanB types of glycopeptide resistance in VRE.
  • To inform strategies for VRE surveillance and control.

Summary:

  • VRE detection in Japanese patients has been limited to eight cases across four hospitals since 1996.
  • A significant source of VRE in Japan appears to be imported chickens exposed to avoparcin.
  • Two acquired glycopeptide resistance types, VanA and VanB, are identified, differing in resistance levels and induction triggers.

Impact:

  • Highlights the potential role of imported food products in VRE transmission.
  • Provides a basis for targeted surveillance of VRE in healthcare and agricultural settings.
  • Contributes to the global understanding of VRE resistance mechanisms and spread.

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