Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glucose metabolism in the developing brain.

R C Vannucci1, S J Vannucci

  • 1Department of Pediatrics, Pennsylvania State University College of Medicine, PennState Geisinger Health System, Hershey 17033-0850, USA.

Seminars in Perinatology
|May 11, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel approach to the study of hypoxia-ischemia-induced clinical and subclinical seizures in the neonatal rat.

Developmental neuroscience·2011
Same author

Arousal-related reticular neurons during reduced oxygen tension: resilience and recovery of electrical activity.

Developmental neuroscience·2009
Same author

Pentylenetetrazol-induced status epilepticus up-regulates the expression of glucose transporter mRNAs but not proteins in the immature rat brain.

Brain research·2006
Same author

Differential effects of hypoxia-ischemia on phosphorylation of the N-methyl-D-aspartate receptor in one- and three-week-old rats.

Developmental neuroscience·2005
Same author

Glucose transport into brain: effects of hypoglycemia.

Diabetes, nutrition & metabolism·2003
Same author

Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation.

Osteoarthritis and cartilage·2003
Same journal

Congenital cytomegalovirus: Screening strategies and diagnostic challenges.

Seminars in perinatology·2026
Same journal

The society for neonatal nutrition and lifelong health: Building science and translating research to inform neonatal nutritional care.

Seminars in perinatology·2026
Same journal

Enteral nutrition to optimize health and neurodevelopmental outcomes in very preterm infants.

Seminars in perinatology·2026
Same journal

Standardizing outcome measures in preterm infant nutrition research: Use of anthropometry and body composition in the neonatal intensive care unit.

Seminars in perinatology·2026
Same journal

A dilemma of parental inclusion? Parent perspectives of NICU feeding practices and neonatal nutritional research.

Seminars in perinatology·2026
Same journal

Maternal diet and nutritional status during pregnancy and lactation: a review of implications on milk composition and lactation outcomes.

Seminars in perinatology·2026
See all related articles

Glucose is the main brain fuel for fetuses and newborns, with utilization increasing with age. The immature brain is protected by glucose during hypoxia-ischemia, unlike in adults.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Metabolism

Background:

  • Glucose is the primary cerebral energy substrate for both adults and the developing brain.
  • Cerebral glucose utilization in the fetus and newborn increases with maturation, showing regional differences.
  • Glucose transporter proteins GLUT1 and GLUT3 expression follows a similar developmental pattern.

Purpose of the Study:

  • To examine the role and regulation of glucose metabolism in the developing brain.
  • To understand how the immature brain utilizes and is affected by glucose compared to adults.
  • To investigate alternative energy substrates and their protective roles in the developing brain.

Main Methods:

  • Review of experimental animal and human studies on cerebral glucose utilization.

Related Experiment Videos

  • Analysis of glucose transporter protein (GLUT1, GLUT3) expression patterns during brain development.
  • Comparison of glucose's role in normal development, hypoxia-ischemia, and hypoglycemia in immature versus adult brains.

    • Main Results:

    • Cerebral glucose utilization and transporter expression increase with brain maturation.
    • Ketone bodies and lactate can serve as alternative fuels, protecting the immature brain during hypoglycemia.
    • Glucose supplementation is protective during hypoxia-ischemia in the immature brain, while hypoglycemia is harmful.

    Conclusions:

    • Glucose is critical for fetal and neonatal brain energy production and biosynthesis.
    • The developing brain has distinct metabolic vulnerabilities and protective mechanisms compared to the adult brain.
    • Understanding these developmental metabolic differences is crucial for managing neurological conditions in newborns.