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[Effect on endothelin and cytokines on the pathogenesis of coronary heart disease]
1Department of Cardiology, Third Affiliated Hospital, Hunan Medical University, Changsha.
Insights
Plasma endothelin (ET) and tumor necrosis factor (TNF) levels are elevated in coronary heart disease (CHD) patients, particularly those with acute myocardial infarction (AMI). Interleukin-6 (IL-6) is also significantly higher in AMI patients, suggesting a role for these markers in CHD pathogenesis.
Area of Science:
- Biochemistry
- Immunology
- Cardiology
Context:
- Coronary heart disease (CHD) is a leading cause of mortality worldwide.
- Biomarkers for CHD pathogenesis are crucial for early diagnosis and treatment.
- Endothelin (ET), tumor necrosis factor (TNF), and interleukin-6 (IL-6) are implicated in cardiovascular inflammation and disease.
Purpose:
- To investigate the plasma levels of endothelin (ET) and serum levels of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in patients with coronary heart disease (CHD).
- To compare these levels between patients with CHD, including acute myocardial infarction (AMI), and healthy controls.
- To elucidate the potential role of ET and cytokines in the pathogenesis of CHD.
Summary:
- Radioimmunoassay and ELISA were used to measure ET, TNF, and IL-6 in 35 CHD patients and 20 healthy controls.
- Plasma ET and serum TNF levels were significantly higher in the CHD group, especially the AMI subgroup, compared to controls (P < 0.01).
- Serum IL-6 levels showed no significant difference in the narrowed coronary artery group but were significantly elevated in the AMI group (P < 0.01).
Impact:
- Findings suggest that elevated ET and cytokine levels, particularly TNF and IL-6 in AMI, are strongly associated with the pathogenesis of coronary heart disease.
- These biomarkers may serve as potential indicators for disease severity and progression in CHD.
- Further research into the specific mechanisms of ET and cytokine involvement could lead to novel therapeutic strategies for CHD.
Abstract:
The plasma levels of endothelin(ET), serum levels of tumor necrosis factor(TNF) and interleukin-6(IL-6) in 35 patients with coronary heart disease(CHD) and 20 healthy people were studied by radioimmunoassay and enzymebinded immunosorbent assay(ELISA). The results showed that the plasma ET level and the serum TNF level in the CHD group, especially the acute myocardial infarction(AMI) group, were much higher than those of the control group (P < 0.01). There was no obvious statistical difference on IL-6 levels between the narrowed coronary artery group and the control group (P > 0.05). But the serum level of IL-6 in the AMI group was significantly higher than that of the other groups (P < 0.01). These findings indicate that ET and cytokine levels may play an important role on the pathogenesis of coronary heart disease.