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HSP60, HSP70 in the pathogenesis of Kawasaki disease: implication and action
Insights
Heat shock proteins (HSP60 and HSP70) in lymphocytes, but not plasma, were significantly elevated in children with Kawasaki disease (KD). Lymphocyte HSP levels may aid in KD diagnosis and understanding its pathogenesis.
Area of Science:
- Immunology
- Pediatrics
- Molecular Biology
Background:
- Kawasaki disease (KD) is an acute febrile illness affecting young children.
- Heat shock proteins (HSPs) are involved in cellular stress responses and immune modulation.
- The role of HSP60 and HSP70 in KD pathogenesis remains incompletely understood.
Purpose of the Study:
- To investigate the levels of HSP60 and HSP70 in plasma and lymphocytes of children with KD.
- To compare HSP levels in KD patients with healthy children and those with other febrile illnesses.
- To assess the diagnostic potential of HSPs in KD.
Main Methods:
- Plasma and lymphocyte levels of HSP60 and HSP70 were measured in KD patients and healthy controls.
- Comparisons were made with patients suffering from febrile diseases and tuberculosis.
- Statistical analyses were performed to determine significant differences between groups.
Main Results:
- Plasma HSP70 showed a significant difference between acute and convalescent KD phases, but HSP60 and HSP70 did not differ significantly in plasma across all groups.
- Lymphocyte HSP60 and HSP70 levels were significantly higher in the acute phase of KD compared to convalescent phase and healthy controls.
- Lymphocyte HSP60 levels in KD were higher than in febrile diseases but lower than in tuberculosis.
Conclusions:
- Lymphocyte HSP60 and HSP70 levels are significantly elevated during the acute phase of Kawasaki disease.
- Measuring HSP60 and HSP70 in lymphocytes may assist in the diagnosis of KD.
- HSP60 and HSP70 may play a role in the pathogenesis of Kawasaki disease.
Abstract:
HSP60, HSP70 in plasma of 11 cases of Kawasaki diseases (KD) and 23 healthy children were determined. The two groups were controlled for age. Determination of HSP60, HSP70 was conducted in lymphocytes of 14 cases of KD and 26 healthy children. The results were compared with those of 12 patients with febrile diseases and 10 patients with tuberculosis. Our results showed that except a significant difference in plasma HSP70 found between acute phase and convalescent phase of KD (P < 0.01), no significant difference was found in HSP60, HSP70 among all groups (P > 0.05). The differences in HSP60, HSP70 in lymphocytes were relatively obvious among all groups. The levels of HSP60, HSP70 in acute phase of KD were significantly higher than those in convalescent phase or in healthy controls (P < 0.01). The levels of HSP60 in KD were significantly higher than those of patients with febrile diseases. HSP60 of KD children was significantly lower than those of children with tuberculosis (P < 0.01). The findings showed that HSP60, HSP70 might contribute to the pathogenesis of KD. Determination of HSP60, HSP70 in lymphocytes is of help in the diagnosis of KD.